Answer :
The molecules that binds type III collagen to the basal lamina are Type VII collagen.
Keratinocytes and fibroblasts are largely responsible for producing type VII collagen (COLVII). It is essential for the extracellular matrix's (ECM) integrity and function because it is an anchoring fibril collagen that binds type I and type III collagen, stabilizing the ECM structures of the interstitial membrane and basement membrane.
The basement zone under stratified squamous epithelia is the only place where the type VII collagen fibril, which is made up of three identical alpha collagen chains, may be found. Between the overlying stroma and the outside epithelia, it serves as an anchoring fibril.
The dystrophic epidermolysis bullosa gene is mutated in all manifestations of the disease. But even in the absence of mutations, an autoimmune reaction to type VII collagen can cause epidermolysis, an acquired version of this illness.
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