An age-related physiologic alteration that affects the pharmacokinetics of medications in elderly patients is decline in creatinine clearance - kidney function, with an increase in age
The absorption, distribution, and elimination of medications (via metabolism and excretion) are all aspects of the pharmacokinetic process. It is clear that pharmacological compounds must overcome several structural and metabolic obstacles. The blood concentration must be one of the factors determining the drug's concentration at the site of action. Only the drug in its free form can be controlled by the body. The best route of medication administration, the pharmaceutical form, and bioequivalence between various preparations are all influenced by drug bioavailability and the variables that may have an impact on it.
Three different types of variables, including those relating to the medicine, the patient, and the environment, can influence how bioavailable a medication is. A slower rate of absorption results in less pharmacological effects following a single oral dosage of the medication but has no impact on the drug's steady-state concentration or its effects. In contrast, Tmax is unaffected by the variables that reduce the quantity of medicine that is accessible in the body by impairing drug absorption. Due to the low steady-state concentration of the medication over long-term treatment, they might, nevertheless, result in therapeutic failure.
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