Fluoroacetate occurs naturally in some plants and is highly toxic to mammals and insects. In cells, it is converted to fluorocitrate, which binds tightly and inhibits an enzyme crucial for cellular respiration, causing citrate buildup. To what enzyme does fluorocitrate bind?.

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mimi4775 mimi4775

25-10-2022
Biology

Answered

Fluoroacetate occurs naturally in some plants and is highly toxic to mammals and insects. In cells, it is converted to fluorocitrate, which binds tightly and inhibits an enzyme crucial for cellular respiration, causing citrate buildup. To what enzyme does fluorocitrate bind?.

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kumarravichandra kumarravichandra · Answer 1 · 2022-11-04T01:16:02-04:00

It is transformed into fluorocitrate in cells, where it binds firmly and prevents an enzyme necessary for cellular respiration, leading to citrate accumulation. Aconitase enzyme and fluorocitrate bind.

The primary pathway for the synthesis of energy features the enzyme aconitase. Citrate is changed into isocitrate as part of the citric acid cycle. Citrate-to-isocitrate conversion is carried out by the citric acid cycle enzyme mitochondrial aconitase. Similar action is taken by an isoform in the cytoplasm. Several TCA cycle intermediates are also biosynthetic precursors of amino acids and heme, in addition to being used as energy sources when carbohydrates are broken down. Additionally, mAcn performs a second crucial function in the upkeep of mitochondrial DNA (mtDNA). In the tricarboxylic acid cycle, aconitase is an enzyme that catalyzes the non-redox-active stereo-specific isomerization of citrate to isocitrate via cis-aconitate. Proteins are made up of amino acids that are connected by one or more polypeptide chains to form enzymes.

Learn more about aconitase here:

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