Edema can also develop due to increased capillary hydraulic pressures or permeability, disturbances of the endothelial glycocalyx, decreased intercellular compliance, lower colloid osmotic pressure, or a combination of these factors.
What happens when vascular permeability increases?
The vascular barrier disintegrates in many diseases, including cancer and chronic inflammatory conditions, and leakage becomes chronic. Edema, inflammation, and, quite often, disease progression result from the leakage of larger molecules and cells.
Edema can also develop due to increased capillary hydraulic pressures or permeability, endothelial glycocalyx disruption, a combination of these, decreased oncotic plasma pressure or decreased interstitial compliance.
Therefore, hydrostatic pressure, oncotic pressure, and the physical side of the barrier separate the blood from the interstitium of the tissue, causing edema.
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