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During pyruvate oxidation pyruvate is converted to a molecule of acetyl. Pyruvate is a 3-carbon molecule while acetyl is a 2-carbon molecule. What do you think happened to the carbon molecule that was lost?.



Answer :

The lost carbon is released in the form of carbon dioxide.

The oxidation of pyruvate to acetyl CoA is a one step process requiring cofactor. The oxidation reaction involves conversion of [tex] {NAD}^{ + } [/tex] to NADH. In the step, [tex] CO_{2}[/tex]

is released.

Also, CoA-SH also enters the reaction for reaction with the molecule of pyruvate. Pyruvate dehydrogenase complex is used for catalysis of reaction. The resultant product is acetyl CoA.

The reaction is a very important intermediate step. It makes the molecule of pyruvate usable for generation of ATP. The acetyl CoA is used in the next step which is Kreb's cycle.

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