Answer :
Parietal cells in the stomach are blocked from producing acids by medicines for heartburn.
Heartburn, commonly known as GERD, is treatable with over-the-counter medications that lower acidity in the stomach. Acidity is created by the release of HCl in the stomach, and this HCl is required for restricting microbial activity and activating pepsinogen to pepsin (for the digestion of proteins in the stomach). When stomach acid returns into the tube that transports food from your mouth to your stomach, it causes heartburn (esophagus). When food is eaten, the lower esophageal sphincter (a ring of muscle surrounding the bottom of the esophagus) relaxes, allowing food and fluids to flow into the stomach.
Parietal cells (also referred as oxyntic cells) are stomach epithelial cells that release HCl and intrinsic factor. These cells are present in the gastric glands, which are situated in the fundus and body areas of the stomach. Parietal cells are in charge of secreting stomach acid, which assists in digestion, mineral absorption, and bacterial control. The parietal cells in the stomach wall create HCl. As a result, these over-the-counter medications work on parietal cells, lowering heartburn and acid output in the stomach.
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