cancers cells with accumulation of other associated cells including tumor associated fibroblast, immune suppressive and immune modulatory, cell make a mass of cell environment called tumor microenvironment (tme).

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14-10-2022
Biology

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cancers cells with accumulation of other associated cells including tumor associated fibroblast, immune suppressive and immune modulatory, cell make a mass of cell environment called tumor microenvironment (tme).

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Baraka1 Baraka1 · Answer 1 · 2022-10-17T11:58:49-04:00

True, the environment surrounding a tumor, including nearby blood arteries, immune cells, fibroblasts, signaling molecules, and the extracellular matrix, is known as the tumor microenvironment (TME) (ECM).

The microenvironment around the tumor and the tumor itself are intertwined and continually interacting. By generating extracellular signals, boosting tumor angiogenesis, and inducing peripheral immunological tolerance, tumors can have an impact on the milieu, whereas immune cells in the microenvironment can influence the development and spread of cancerous cells. The tumor interacts closely with the surrounding microenvironment, which is known to profoundly impact tumor progression by influencing processes that lead to tumor eradication, increased metastasis, or the establishment of dormant micrometastases.

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