Answer:
$2,081.00
Step-by-step explanation:
You want to know how much more $4,622.00 is than $2,541.00.
The wording "how much more" usually refers to the difference, the value that results from subtracting the smaller number from the larger one.
In this case, that is ...
$4622 -2541 = $2081
The first place winner got $2,081.00 more than the runner-up.
__
Additional comment
The wording "how many times more" usually refers to the ratio, the value that results from dividing the larger number by the smaller one.