Answer :
An early precursor to the development of neurofibrillary tangles and the neurodegeneration seen in Alzheimer disease, hyperphosphorylated tau protein (AT8 antibody) accumulates in transgenic mice overexpressing the RCAN1-1L protein.
Rats subjected to stress caused by immobility or isolation have higher levels in their hippocampus. Stress was applied to adult rats. Male Wistar rats that are eleven weeks old are cared for and worked on.
Acute stress may be protected against by transiently inducing the RCAN1 gene, but ongoing stress may lead to chronic RCAN1 overexpression, which can have dangerous side consequences. RCAN1 protein levels that are persistently increased may induce or aggravate a number of illnesses, including tauopathies like Alzheimer's disease. Through the inhibition of calcineurin and the stimulation of GSK-3 by RCAN1 proteins, stress can cause various disorders.
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