Answer :
A single stranded DNA (oligonucleotides) can hybridize with complementary RNA.
What is oligonucleotides?
Short DNA or RNA molecules called oligonucleotides have several uses in forensic science, genetic research, and testing. These tiny pieces of nucleic acids, which are frequently produced in the lab by solid-phase chemical synthesis and can be produced as single-stranded molecules with any user-specified sequence, are essential for artificial gene synthesis, polymerase chain reaction (PCR), DNA sequencing, molecular cloning, and the use of molecular probes. Ordinarily, oligonucleotides can be found in nature as small RNA molecules that control the expression of genes or as intermediates in the decay of bigger nucleic acid molecules.
Antisense oligonucleotides are single-stranded DNA sequences that bind to complementary locations in mRNAs and prevent translation by encouraging RNase H to cleave the RNA strand in mRNA-DNA hybrids. They are typically 15 to 25 nucleotides in length.
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