Messenger molecule bind with specific target proteins, to cause some effect on the target cell.
- Target proteins are useful biomolecules that biologically active substances interact with and regulate.
- They are utilized during the transduction, transformation, and conjugation processes.
- An developing therapeutic approach known as targeted protein degradation (TPD) has the potential to address disease-causing proteins that have hitherto been very difficult to target with traditional small molecules.
- Proteases, kinases, G protein-coupled receptors (GPCRs), and nuclear hormone receptors are currently the protein targets for which effective medicines have been produced.
- Typically bioactive small compounds are coupled onto solid supports and then used to separate target proteins from the entire proteome for target protein identification.
- High binding affinity between bioactive small molecules and their intended protein targets is necessary for this method.
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