The correct statements are:
A bind GTP
B open an ion channel and
C raise cytosolic calcium
- The majority of cellular responses to environmental inputs are mediated by G protein-coupled receptors (GPCRs).
- Upon ligand activation of the receptor, it binds to heterotrimeric G protein partners, facilitates the exchange of GTP to GDP, cleaves the G protein into subunits, and mediates downstream signaling.
- Arrestins also enable GPCRs to activate multiple signaling pathways. Small modifications at the ligand-binding or orthosteric sites are amplified to produce larger conformational changes, translocating the GPCR to its active state.
- Structures, spectroscopic data, and computer simulations of various GPCRs crystallized in active and inactive states provide molecular knowledge of allosteric coupling between ligand binding and G-protein or arrestin interactions. Instead of being adjusted, the connection is loose.
Therefore, option e. is correct.
Learn more about GPCR:
https://brainly.com/question/13186034
#SPJ4
