Answer :
English settlers and Indians had good and bad interactions and conflicts. Since the English stole Indian territory, their relationship was adversarial. When not at war with the Natives, the English forced commerce.
After the first and second Anglo-Powhatan wars, English sickness ended their peace deal. As the English were determined to exterminate the Natives, they lacked food, forcing many to starve. Neither English nor Indians benefited from their interactions.
This is further explained below.
How did the interaction and conflict between English settlers and Indians affect both parties, and contribute to developments that neither group sought?
Generally, Both English settlers and Indians benefited and suffered from their involvement in the battle between the two groups. The relationship between the English settlers and the Indians was fraught and antagonistic when the Europeans stole Indian territory.
The English fought the Native Americans often, reducing their numbers, and when they weren't at war, they forced commerce. After the first and second Anglo-Powhatan wars, the peace deal between the two sides was broken because the English had introduced illnesses to the natives.
In conclusion, many Native Americans perished from starvation because the English were so intent on eradicating them that they stunted agricultural production. Therefore, the interactions between the English and the Indians were of little advantage to either culture.
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