In humans, albinism is normally inherited in an autosomal recessive fashion. It has been observed that two albino parents can have several children, none of whom is an albino.
a. Interpret this inheritance pattern in terms of a complementation test.
b. It is unusual to find examples of human pedigrees such as the one described that in effect represent a complementatio test. The reason is that most genetic conditions in humans are rare, so it is unlikely that unrelated people with the samecondition would mate. In the absence of complementation testing, what kinds of experiments could be done to determine whether a particular human disease can be caused by mutations at more than one gene?
c. Complementation testing requires that the two mutations to be tested are both recessive to wild type. Suppose that two dominant mutations cause similar mutant phenotypes. How could you establish whether these mutations affected the same gene or different genes?