Yes, there would be a noticeable change if 10% glucose is substituted with 10% orange juice. Glucose is a simple sugar, while orange juice contains a mixture of sugars, primarily fructose, glucose, and sucrose, along with various acids, vitamins, and other compounds.

1. **Taste**: The most obvious change would be in taste. Glucose has a neutral taste, while orange juice is sweet and tangy due to its natural sugars and acids.

2. **Nutritional Content**: Orange juice contains additional nutrients such as vitamin C, potassium, and antioxidants, which are not present in glucose.

3. **Acidity**: Orange juice is acidic due to the presence of citric acid and other organic acids, whereas glucose solution is neutral. This difference in acidity can affect certain reactions and biological processes.

4. **Color**: Orange juice has a distinct color due to the presence of pigments like carotenoids, which would cause a change in the solution's color compared to clear glucose solution.

Overall, substituting glucose with orange juice would result in a noticeable change in taste, nutritional content, acidity, color, and potentially other properties of the solution.