Determine whether the following phrases describe type I topoisomerases, type II topoisomerases, or both type I and type II topoisomerases. Type I Topoisomerases Type II topoisomerases Bothcleave one strand of DNA cleave both DNA strands couples energy from ATP hydrolysis to the introduction of negative supercoils change the linking number (Lk)by a multiple of 2 change the linking number (Lk)by 1 or a multiple of 1 regulate DNA supercoiling



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