Practice FRQ
1. You are working in a research lab and your goal is to determine the effect that alcohol has on the liver.
You design an experiment where you expose samples of liver tissues to varying concentrations of
alcohol as follows:
Sample
Sample 1
Sample 2
Sample 3
Concentration of alcohol
0.25 mg/ml.
0.35 mg/mL
0.45 mg/mL
Duration of exposure
20 minutes
20 minutes
20 minutes
After exposure to the alcohol, you analyze the liver samples. In all samples you find that the alcohol
has been broken down (detoxified). However, in sample 3 you find damage to organelles has occured
due to the high concentration of alcohol. (a) Identify one organelle in the liver that could be responsible
for the detoxification of the alcohol in all three samples. (b) In sample 3 identify the organelle that
would most likely be responsible for removing the damaged parts of organelles and (c) describe the
steps it would take to do so.