Ras Homework
Wild type
cells without
growth factor
Wild type
cells with
growth factor
Mutations that
keep Ras in
the GTP-
bound form
Mutations that
keep Ras in
the GDP-
bound form
Mutations that
inactivate
GAP
Mutations that
overexpress
RTK
Receptor
Tyrosine
Kinase
Off
On
due April 23, 2019
Ras
GDP-bound
GTP-bound
Name
ERK
Inactive,
Not
phosphorylated
Active,
Phosphorylated
Cell
Proliferation
No
proliferation
Proliferation