Question 6 The Impact of Spanish Colonization Text 6 Question 6. What was one of the impacts of Spanish colonization on Native Americans? A. The Maya and the Incas, realizing victory was impossible, surrendered and never again fought against the Spanish. B. Native Americans lost most parts of their culture. C. Tens of thousands of Native Americans died from disease, war, and forced labor. D. Native American culture became the dominant aspect of Latin American culture.