What is the function of the enzyme topoisomerase in DNA replication? (A) relieving strain in the DNA ahead of the replication fork caused by the untwisting of the double helix (B) elongating new DNA at a replication fork by adding nucleotides to the existing chain (C) reattaching the hydrogen bonds between the base pairs in the double helix (D) building RNA primers using the parental DNA strand as a template

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23-08-2022
Biology

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What is the function of the enzyme topoisomerase in DNA replication? (A) relieving strain in the DNA ahead of the replication fork caused by the untwisting of the double helix (B) elongating new DNA at a replication fork by adding nucleotides to the existing chain (C) reattaching the hydrogen bonds between the base pairs in the double helix (D) building RNA primers using the parental DNA strand as a template

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AakanshaC AakanshaC · Answer 1 · 2022-08-31T06:17:30-04:00

The function of the enzyme topoisomerase in DNA replication is relieving strain in the DNA ahead of the replication fork caused by the untwisting of the double helix.

Nuclear enzymes known as topoisomerases are crucial for DNA replication, transcription, chromosome segregation, and recombination. These enzymes come in two main varieties; type I enzymes pass one or two DNA strands through the break before sealing it, whereas type II molecules cleave both DNA strands simultaneously and religate the double-strand break after passing another double strand through the break. By splitting, swiveling, and reconnecting DNA strands, a topoisomerase corrects "overwinding" before replication forks. This enzyme, to put it simply, stops the DNA double helix before the replication fork from becoming too wrapped as the DNA is opened up. Therefore, this enzyme stops DNA from supercoiling.

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