Answer :
Binding of a signalling molecule to a ligand-gated ion channel receptor, that leads directly to a change in the distribution of ions on opposite sides of the membrane.
Ligand-gated ion channels are also generally referred to as ionotropic receptors, and these are a group of transmembrane ion-channel proteins which are open to allow ions such as K⁺, Ca²⁺, Na⁺ , or Cl⁻ to easily pass through the membrane in order to respond to the binding of chemical messengers (neurotransmitter).
In a ligand-gated ion channel, the substances will be distributed from outside to inside (or vice versa, depending on the type of substances). Ligand-gated ion channels that binds neurotransmitters and open in response to the ligand binding.
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