Answer :
Chloride ions outside the neuron would make it very difficult for a depolarization to occur.
In a normal resting state, the internal environment of a neuron has a net negative charge compared to the external environment.
This is known as the resting potential. During depolarization, this membrane potential switches from negative to positive very rapidly due to an influx of positively-charged cations (such as sodium) into the cell.
To interfere with this process, the ions outside of the neuron would have to shift the normal resting state so that the internal environment of the cell no longer has a net negative charge.
This will prevent the influx of cations that will cause depolarization. In order to do this, we would need to balance out the negative charge inside the cell with negative charge outside of the cell. In the list of options, chloride is the only negatively-charged ion. Therefore, the answer would be Chloride.
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